CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90
The molecular chaperone Hsp90 sequesters oncogenic mutants of the tumor suppressor p53 that have unstable core domains. It is not known whether p53 is bound in an unfolded, partly folded, or distorted structure, as is unknown for the structure of any bound substrate of Hsp90. It is a particularly di...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163643/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132393699 |
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