Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis

SOS mutagenesis in Escherichia coli requires DNA polymerase V (pol V) and RecA protein to copy damaged DNA templates. Here we show that two distinct biochemical modes for RecA protein are necessary for pol V-catalyzed translesion synthesis. One RecA mode is characterized by a strong stimulation in n...

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Detalhes bibliográficos
Main Authors: Pham, Phuong, Seitz, Erica M., Saveliev, Sergei, Shen, Xuan, Woodgate, Roger, Cox, Michael M., Goodman, Myron F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123210/
https://ncbi.nlm.nih.gov/pubmed/12177433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.172197099
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