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Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex

Insulator DNAs and promoter competition regulate enhancer–promoter interactions within complex genetic loci. Here we provide evidence for a third mechanism: promoter-proximal tethering elements. The Scr-ftz region of the Antennapedia gene complex includes two known enhancers, AE1 and T1. AE1 selecti...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Calhoun, Vincent C., Stathopoulos, Angelike, Levine, Michael
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123125/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093913/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142291299
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