Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation
Prp8 is the largest and most highly conserved protein in the spliceosome yet its mechanism of function is poorly understood. Our previous studies implicate Prp8 in control of spliceosome activation for the first catalytic step of splicing, because substitutions in five distinct regions (a–e) of Prp8...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087126/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102304299 |
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