Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation
Prp8 is the largest and most highly conserved protein in the spliceosome yet its mechanism of function is poorly understood. Our previous studies implicate Prp8 in control of spliceosome activation for the first catalytic step of splicing, because substitutions in five distinct regions (a–e) of Prp8...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087126/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102304299 |
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