Extensive Antigenic Polymorphism within the Repeat Sequence of the Plasmodium falciparum Merozoite Surface Protein 1 Block 2 Is Incorporated in a Minimal Polyvalent Immunogen

Polymorphism in pathogen antigens presents a complex challenge for vaccine design. A prime example is the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP1), to which allele-specific antibodies have been associated with protection from malaria. In a Zambian pop...

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Bibliographic Details
Main Authors: Tetteh, Kevin K. A., Cavanagh, David R., Corran, Patrick, Musonda, Rosemary, McBride, Jana S., Conway, David J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1231057/
https://ncbi.nlm.nih.gov/pubmed/16113313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.9.5928-5935.2005
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