Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism

Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are ind...

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Autori principali: Elass, Elisabeth, Aubry, Laëtitia, Masson, Maryse, Denys, Agnès, Guérardel, Yann, Maes, Emmanuel, Legrand, Dominique, Mazurier, Joël, Kremer, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Host Response and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230978/
https://ncbi.nlm.nih.gov/pubmed/16177394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.7064-7068.2005
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