Lactoferrin Inhibits the Lipopolysaccharide-Induced Expression and Proteoglycan-Binding Ability of Interleukin-8 in Human Endothelial Cells

Interleukin-8 (IL-8), a C-X-C chemokine bound to endothelium proteoglycans, initiates the activation and selective recruitment of leukocytes at inflammatory foci. We demonstrate that human lactoferrin, an antimicrobial lipopolysaccharide (LPS)-binding protein, decreases both IL-8 mRNA and protein ex...

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Detalles Bibliográficos
Main Authors: Elass, Elisabeth, Masson, Maryse, Mazurier, Joël, Legrand, Dominique
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2002
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC127826/
https://ncbi.nlm.nih.gov/pubmed/11895948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.4.1860-1866.2002
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