Poly-N-Acetylglucosamine Production in Staphylococcus aureus Is Essential for Virulence in Murine Models of Systemic Infection

The contribution of the Staphylococcus aureus surface polysaccharide poly-N-acetylglucosamine (PNAG) to virulence was evaluated in three mouse models of systemic infection: bacteremia, renal abscess formation, and lethality following high-dose intraperitoneal (i.p.) infection. Deletion of the interc...

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Autori principali: Kropec, Andrea, Maira-Litran, Tomas, Jefferson, Kimberly K., Grout, Martha, Cramton, Sarah E., Götz, Friedrich, Goldmann, Donald A., Pier, Gerald B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230935/
https://ncbi.nlm.nih.gov/pubmed/16177366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6868-6876.2005
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