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Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels
Rod cyclic nucleotide-gated (CNG) channels are heterotetramers comprised of both CNGA1 and CNGB1 subunits. Calcium/calmodulin (Ca(2+)/CaM) binds to a site in the N-terminal region of CNGB1 subunits and inhibits the opening conformational change in CNGA1/CNGB1 channels. Here, we show that polypeptide...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123083/ https://ncbi.nlm.nih.gov/pubmed/12048242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122015999 |
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