Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix remodeling. However, specific roles remain to be validated in vivo. Here we show that combined deficiency of cathepsins B and L in mice is lethal during the second to four...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Felbor, Ute, Kessler, Benedikt, Mothes, Walther, Goebel, Hans H., Ploegh, Hidde L., Bronson, Roderick T., Olsen, Bjorn R.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2002
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122989/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.112632299
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