QR Code

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix remodeling. However, specific roles remain to be validated in vivo. Here we show that combined deficiency of cathepsins B and L in mice is lethal during the second to four...

Full description

Saved in:
Published in:Proc Natl Acad Sci U S A
Main Authors: Felbor, Ute, Kessler, Benedikt, Mothes, Walther, Goebel, Hans H., Ploegh, Hidde L., Bronson, Roderick T., Olsen, Bjorn R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048238/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.112632299
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items