Pregnancy status and fetal prion genetics determine PrP(Sc) accumulation in placentomes of scrapie-infected sheep

Ovine scrapie is a fatal neurodegenerative disorder that may be transmitted through exposure to infected uterine and placental tissues. Susceptibility to scrapie is primarily controlled by polymorphisms in the prion protein (PrP) gene. Scrapie in the U.S. Suffolk breed and in many breeds in Europe o...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Tuo, Wenbin, O'Rourke, Katherine I., Zhuang, Dongyue, Cheevers, William P., Spraker, Terry R., Knowles, Donald P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122945/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072071199
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