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Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus

Continual mutations to the hemagglutinin (HA) gene of influenza A virus generate novel antigenic strains that cause annual epidemics. Using a database of 560 viral RNA sequences, we study the structure and tempo of HA evolution over the past two decades. We detect a critical length scale, in amino a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Plotkin, Joshua B., Dushoff, Jonathan, Levin, Simon A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122937/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11972025/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082110799
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