A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by methyltransferases that use the universal methyl donor S-adenosyl-l-methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolat...

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Detalhes bibliográficos
Main Authors: Friso, Simonetta, Choi, Sang-Woon, Girelli, Domenico, Mason, Joel B., Dolnikowski, Gregory G., Bagley, Pamela J., Olivieri, Oliviero, Jacques, Paul F., Rosenberg, Irwin H., Corrocher, Roberto, Selhub, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122817/
https://ncbi.nlm.nih.gov/pubmed/11929966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062066299
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