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CD40 stimulation leads to effective therapy of CD40(−) tumors through induction of strong systemic cytotoxic T lymphocyte immunity

Adequate spontaneous activation of tumor-specific T lymphocytes in tumor-bearing hosts is rare, despite the expression of tumor antigens that are potentially highly immunogenic. For example, failure of the immune system to raise competent responses against established tumors expressing the human ade...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: van Mierlo, Geertje J. D., den Boer, Annemieke Th., Medema, Jan Paul, van der Voort, Ellen I. H., Fransen, Marieke F., Offringa, Rienk, Melief, Cornelis J. M., Toes, Rene E. M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122809/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11929985/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082107699
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