CD40 stimulation leads to effective therapy of CD40(−) tumors through induction of strong systemic cytotoxic T lymphocyte immunity

Adequate spontaneous activation of tumor-specific T lymphocytes in tumor-bearing hosts is rare, despite the expression of tumor antigens that are potentially highly immunogenic. For example, failure of the immune system to raise competent responses against established tumors expressing the human ade...

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Détails bibliographiques
Auteurs principaux: van Mierlo, Geertje J. D., den Boer, Annemieke Th., Medema, Jan Paul, van der Voort, Ellen I. H., Fransen, Marieke F., Offringa, Rienk, Melief, Cornelis J. M., Toes, Rene E. M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC122809/
https://ncbi.nlm.nih.gov/pubmed/11929985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082107699
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