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Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

Polyinosinic-polycytidylic acid (PolyIC), a “mimic” of double-stranded viral RNA, can induce diabetes when administered to rats with RT1(u), and immunization of normal H-2(d) mice (e.g., BALB/c) with insulin B:9–23 peptide (but not H-2(b)) results in the rapid induction of insulin autoantibodies. Be...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Moriyama, Hiroaki, Wen, Li, Abiru, Norio, Liu, Edwin, Yu, Liping, Miao, Dongmei, Gianani, Roberto, Wong, F. Susan, Eisenbarth, George S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122805/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11943868/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082120099
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