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Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide
Polyinosinic-polycytidylic acid (PolyIC), a “mimic” of double-stranded viral RNA, can induce diabetes when administered to rats with RT1(u), and immunization of normal H-2(d) mice (e.g., BALB/c) with insulin B:9–23 peptide (but not H-2(b)) results in the rapid induction of insulin autoantibodies. Be...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122805/ https://ncbi.nlm.nih.gov/pubmed/11943868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082120099 |
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