Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia

Patients with chronic lymphocytic leukemia (CLL) treated with adenovirus (Ad)-CD154 (CD40L) gene therapy experience reductions in leukemia cell counts and lymph node size associated with induction of the death receptor Fas (CD95). CD4 T cell lines can induce apoptosis of CD40-activated CLL cells via...

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Detalhes bibliográficos
Main Authors: Chu, Peter, Deforce, Dieter, Pedersen, Irene M., Kim, Youngsoo, Kitada, Shinichi, Reed, John C., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122613/
https://ncbi.nlm.nih.gov/pubmed/11891278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022604399
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