The Frequency of Hereditary Defective Mismatch Repair in a Prospective Series of Unselected Colorectal Carcinomas

A comprehensive analysis of somatic and germline mutations related to DNA mismatch–repair (MMR) genes can clarify the prevalence and mechanism of inactivation in colorectal carcinoma (CRC). In the present study, 257 unselected patients referred for CRC resection were examined for evidence of defecti...

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Autors principals: Cunningham, Julie M., Kim, Cheong-Yong, Christensen, Eric R., Tester, David J., Parc, Yann, Burgart, Lawrence J., Halling, Kevin C., McDonnell, Shannon K., Schaid, Daniel J., Walsh Vockley, Catherine, Kubly, Vickie, Nelson, Heidi, Michels, Virginia V., Thibodeau, Stephen N.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Human Genetics 2001
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1226064/
https://ncbi.nlm.nih.gov/pubmed/11524701
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