DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

DNA-dependent protein kinase (DNA-PK), composed of Ku70, Ku80, and the catalytic subunit (DNA-PKcs), is involved in repairing double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ). Certain proteins involved in NHEJ are also involved in DSB repair by homologous recombination (HR). To test t...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Allen, Chris, Kurimasa, Akihiro, Brenneman, Mark A., Chen, David J., Nickoloff, Jac A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904432/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052545899
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