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DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

DNA-dependent protein kinase (DNA-PK), composed of Ku70, Ku80, and the catalytic subunit (DNA-PKcs), is involved in repairing double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ). Certain proteins involved in NHEJ are also involved in DSB repair by homologous recombination (HR). To test t...

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Hlavní autoři: Allen, Chris, Kurimasa, Akihiro, Brenneman, Mark A., Chen, David J., Nickoloff, Jac A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC122597/
https://ncbi.nlm.nih.gov/pubmed/11904432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052545899
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