Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1(−/−)NP2(−/−)) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but h...

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Dades bibliogràfiques
Autors principals: Takashima, Seiji, Kitakaze, Masafumi, Asakura, Masanori, Asanuma, Hiroshi, Sanada, Shoji, Tashiro, Fumi, Niwa, Hitoshi, Miyazaki, Jun-ichi, Hirota, Seiichi, Kitamura, Yukihiko, Kitsukawa, Takashi, Fujisawa, Hajime, Klagsbrun, Michael, Hori, Masatsugu
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC122579/
https://ncbi.nlm.nih.gov/pubmed/11891274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022017899
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