Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1(−/−)NP2(−/−)) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but h...

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Detalhes bibliográficos
Main Authors: Takashima, Seiji, Kitakaze, Masafumi, Asakura, Masanori, Asanuma, Hiroshi, Sanada, Shoji, Tashiro, Fumi, Niwa, Hitoshi, Miyazaki, Jun-ichi, Hirota, Seiichi, Kitamura, Yukihiko, Kitsukawa, Takashi, Fujisawa, Hajime, Klagsbrun, Michael, Hori, Masatsugu
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122579/
https://ncbi.nlm.nih.gov/pubmed/11891274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022017899
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