Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert

Prolonged growth of murine embryonic stem (ES) cells lacking the telomerase reverse transcriptase, mTert, results in a loss of telomere DNA and an increased incidence of end-to-end fusions and aneuploidy. Furthermore, loss of only one copy of mTert also results in telomere shortening intermediate be...

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Main Authors: Liu, Yie, Kha, Hue, Ungrin, Mark, Robinson, Murray O., Harrington, Lea
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC122569/
https://ncbi.nlm.nih.gov/pubmed/11904422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062549199
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