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The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field.

The rat brain IIa (BrIIa) Na channel alpha-subunit and the brain beta 1 subunit were coexpressed in Xenopus oocytes, and peak whole-oocyte Na current (INa) was measured at a test potential of -10 mV. Hyperpolarization of the holding potential resulted in an increased affinity of STX and TTX rested-s...

詳細記述

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書誌詳細
主要な著者: Satin, J., Limberis, J. T., Kyle, J. W., Rogart, R. B., Fozzard, H. A.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 1994
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1225453/
https://ncbi.nlm.nih.gov/pubmed/7811911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0006-3495(94)80566-1
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