Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression

Human cells exposed to antifolates show a rapid increase in the levels of the enzyme dihydrofolate reductase (DHFR). We hypothesized that this adaptive response mechanism can be used to elevate cellular levels of proteins fused to DHFR. In this study, mouse cells transfected to express a green fluor...

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Detaylı Bibliyografya
Asıl Yazarlar: Mayer-Kuckuk, Philipp, Banerjee, Debabrata, Malhotra, Sundeep, Doubrovin, Mikhail, Iwamoto, Marian, Akhurst, Tim, Balatoni, Julius, Bornmann, William, Finn, Ronald, Larson, Steven, Fong, Yuman, Gelovani Tjuvajev, Juri, Blasberg, Ronald, Bertino, Joseph R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC122535/
https://ncbi.nlm.nih.gov/pubmed/11891321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062036899
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