Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression

Human cells exposed to antifolates show a rapid increase in the levels of the enzyme dihydrofolate reductase (DHFR). We hypothesized that this adaptive response mechanism can be used to elevate cellular levels of proteins fused to DHFR. In this study, mouse cells transfected to express a green fluor...

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Autori principali: Mayer-Kuckuk, Philipp, Banerjee, Debabrata, Malhotra, Sundeep, Doubrovin, Mikhail, Iwamoto, Marian, Akhurst, Tim, Balatoni, Julius, Bornmann, William, Finn, Ronald, Larson, Steven, Fong, Yuman, Gelovani Tjuvajev, Juri, Blasberg, Ronald, Bertino, Joseph R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC122535/
https://ncbi.nlm.nih.gov/pubmed/11891321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062036899
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