Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

OBJECTIVES: Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies. METHOD: Using simulated two-generation families with and without parents, we conducted non-parametric multipoint linkage analy...

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Hauptverfasser: Boyles, Abee L., Scott, William K., Martin, Eden R., Schmidt, Silke, Li, Yi-Ju, Ashley-Koch, Allison, Bass, Meredyth P., Schmidt, Michael, Pericak-Vance, Margaret A., Speer, Marcy C., Hauser, Elizabeth R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224705/
https://ncbi.nlm.nih.gov/pubmed/16093727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000087122
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