Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires

Molecular wires comprising a Ru(II)- or Re(I)-complex head group, an aromatic tail group, and an alkane linker reversibly inhibit the activity of the copper amine oxidase from Arthrobacter globiformis (AGAO), with K(i) values between 6 μM and 37 nM. In the crystal structure of a Ru(II)-wire:AGAO con...

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Bibliographische Detailangaben
Hauptverfasser: Contakes, Stephen M., Juda, Gregory A., Langley, David B., Halpern-Manners, Nicholas W., Duff, Anthony P., Dunn, Alexander R., Gray, Harry B., Dooley, David M., Guss, J. Mitchell, Freeman, Hans C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224652/
https://ncbi.nlm.nih.gov/pubmed/16157884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506336102
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