Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
The p53 tumor suppressor gene is the most frequently mutated gene in human cancers, and germ-line p53 mutations cause a familial predisposition for cancer. Germ-line or sporadic p53 mutations are usually missense and typically affect the central DNA-binding domain of the protein. Because p53 functio...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052713099 |
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