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Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

The p53 tumor suppressor gene is the most frequently mutated gene in human cancers, and germ-line p53 mutations cause a familial predisposition for cancer. Germ-line or sporadic p53 mutations are usually missense and typically affect the central DNA-binding domain of the protein. Because p53 functio...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: de Vries, Annemieke, Flores, Elsa R., Miranda, Barbara, Hsieh, Harn-Mei, van Oostrom, Conny Th. M., Sage, Julien, Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122453/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867759/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052713099
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