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α-Helical stabilization by side chain shielding of backbone hydrogen bonds

We study atomic models of the thermodynamics of the structural transition of peptides that form α-helices. The effect of sequence variation on α-helix formation for alanine-rich peptides, Ac-Ala(21)- methyl amide (A21) and Ac-A(5) (AAARA)(3)A-methyl amide (Fs peptide), is investigated by atomic simu...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: García, Angel E., Sanbonmatsu, Kevin Y.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122425/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867710/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042496899
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