Nucleotides and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter.

The human ABC (ATP-binding cassette) transporter MRP1 (human multidrug-resistance-associated protein 1; ABCC1) is involved in the cellular extrusion of conjugated metabolites and causes multidrug resistance in tumour cells. The transport of substrate molecules by ABC proteins is energized by ATP hyd...

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Main Authors: Kern, András, Szentpétery, Zsófia, Liliom, Károly, Bakos, Eva, Sarkadi, Balázs, Váradi, András
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224167/
https://ncbi.nlm.nih.gov/pubmed/14759224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031607
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