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Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C.

IFN-gamma (interferon-gamma) modulates IFN-alpha therapy in chronic hepatitis C infection; however, the underlying mechanism remains unclear. Here we demonstrate that long-term (3-6 days) but not short-term (up to 1 day) IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activati...

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Detalhes bibliográficos
Main Authors: Radaeva, Svetlana, Jaruga, Barbara, Kim, Won-Ho, Heller, Theo, Liang, T Jake, Gao, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224051/
https://ncbi.nlm.nih.gov/pubmed/14690454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031495
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