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Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage.
Oxidative damage to nuclear DNA is known to involve site-specific Fenton-type chemistry catalysed by redox-active iron or copper in the immediate vicinity of DNA. However, the presence of transition metals in the nucleus has not been shown convincingly. Recently, it was proposed that a major part of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224032/ https://ncbi.nlm.nih.gov/pubmed/14670081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031029 |
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