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Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis

Jurkat cells in culture were exposed to oxidative stress in the form of continuously generated hydrogen peroxide, obtained by the addition of glucose oxidase to the medium. This treatment induced a rapid, dose-dependent increase in the ICIP (intracellular calcein-chelatable iron pool). Early destabi...

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Detalhes bibliográficos
Main Authors: Tenopoulou, Margarita, Doulias, Paschalis-Thomas, Barbouti, Alexandra, Brunk, Ulf, Galaris, Dimitrios
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135000/
https://ncbi.nlm.nih.gov/pubmed/15579135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041650
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