Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, yet the mechanisms regulating nuclear/cytoplasmic shuttling of FOXO1 are poorly understood. Previous studies have id...

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Hlavní autoři: Zhao, Xiangshan, Gan, Lixia, Pan, Haiyun, Kan, Donghui, Majeski, Michael, Adam, Stephen A, Unterman, Terry G
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224024/
https://ncbi.nlm.nih.gov/pubmed/14664696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031450
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