Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.

Glycoproteins GPVI and GPIb-IX-V stimulate robust tyrosine phosphorylation of Syk and PLCg2 (phospholipase Cg2) in washed platelets, but only the former stimulates pronounced activation of phospholipase. Using phospho-specific antibodies, we demonstrate that GPVI, but not GPIb-IX-V, stimulates signi...

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Main Authors: Suzuki-Inoue, Katsue, Wilde, Jonathan I, Andrews, Robert K, Auger, Jocelyn M, Siraganian, Reuben P, Sekiya, Fujio, Rhee, Sue Goo, Watson, Steve P
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224016/
https://ncbi.nlm.nih.gov/pubmed/14656219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031430
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