Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP.

CPSase (carbamoyl-phosphate synthetase II), a component of CAD protein (multienzymic protein with CPSase, aspartate transcarbamylase and dihydro-orotase activities), catalyses the regulated steps in the de novo synthesis of pyrimidines. Unlike the orthologous Escherichia coli enzyme that is regulate...

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Detalhes bibliográficos
Main Authors: Simmons, Christine Q, Simmons, Alan J, Haubner, Aaron, Ream, Amber, Davidson, Jeffrey N
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224011/
https://ncbi.nlm.nih.gov/pubmed/14651476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031228
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