Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB.

The general transcription factor, TFIIB, plays an important role in the assembly of the pre-initiation complex. The N-terminal domain (NTD) of TFIIB contains a zinc-ribbon motif, which is responsible for the recruitment of RNA polymerase II and TFIIF to the core promoter region. Although zinc-ribbon...

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Détails bibliographiques
Auteurs principaux: Ghosh, Mahua, Elsby, Laura M, Mal, Tapas K, Gooding, Jane M, Roberts, Stefan G E, Ikura, Mitsuhiko
Format: Artigo
Langue:Inglês
Publié: 2004
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223989/
https://ncbi.nlm.nih.gov/pubmed/14641108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031706
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