The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.

The immediate early response of cells treated with IL-6 (interleukin-6) is the activation of the signal transducer and activator of transcription (STAT)3. The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine signalling)...

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Main Authors: Fischer, Patrick, Lehmann, Ute, Sobota, Radoslaw M, Schmitz, Jochen, Niemand, Claudia, Linnemann, Sonja, Haan, Serge, Behrmann, Iris, Yoshimura, Akihiko, Johnston, James A, Müller-Newen, Gerhard, Heinrich, Peter C, Schaper, Fred
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223960/
https://ncbi.nlm.nih.gov/pubmed/14611646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030893
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