Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.

Abnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett's oesophageal premalignant lesion associated with an increase in mucin-producing goblet cells and MUC4 mucin gene overexpression. However, the molecular mechanisms underlying the regulation of MUC4 by...

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Main Authors: Mariette, Christophe, Perrais, Michaël, Leteurtre, Emmanuelle, Jonckheere, Nicolas, Hémon, Brigitte, Pigny, Pascal, Batra, Surinder, Aubert, Jean-Pierre, Triboulet, Jean-Pierre, Van Seuningen, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223911/
https://ncbi.nlm.nih.gov/pubmed/14583090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031132
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