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The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family
The fluorinated analog of deoxycytidine, Gemcitabine (Gemzar®), is the main chemotherapy in pancreatic cancer, but survival remains weak mainly because of the high resistance of tumors to the drug. Recent works have shown that the mucin MUC4 may confer an advantage to pancreatic tumor cells by modif...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936121/ https://ncbi.nlm.nih.gov/pubmed/22580602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.179 |
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