Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.

The present study describes the in vivo detection and imaging of tumour-associated MMP-7 (matrix metalloproteinase-7 or matrilysin) activity using a novel polymer-based fluorogenic substrate PB-M7VIS, which serves as a selective 'proteolytic beacon' (PB) for this metalloproteinase. PB-M7VI...

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Bibliographic Details
Main Authors: McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, Matrisian, Lynn M
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223892/
https://ncbi.nlm.nih.gov/pubmed/14556651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030582
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