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In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.

In tumour cells, elevated levels of mitochondria-bound isoforms of hexokinase (HK-I and HK-II) result in the evasion of apoptosis, thereby allowing the cells to continue proliferating. The molecular mechanisms by which bound HK promotes cell survival are not yet fully understood. Our studies relying...

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Main Authors: Azoulay-Zohar, Heftsi, Israelson, Adrian, Abu-Hamad, Salah, Shoshan-Barmatz, Varda
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223882/
https://ncbi.nlm.nih.gov/pubmed/14561215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031465
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