Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.

CoTX1 (cobatoxin 1) is a 32-residue toxin with three disulphide bridges that has been isolated from the venom of the Mexican scorpion Centruroides noxius Hoffmann. Here we report the chemical synthesis, disulphide bridge organization, 3-D (three-dimensional) solution structure determination, pharmac...

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Detalhes bibliográficos
Main Authors: Jouirou, Besma, Mosbah, Amor, Visan, Violeta, Grissmer, Stephan, M'Barek, Sarrah, Fajloun, Ziad, Van Rietschoten, Jurphaas, Devaux, Christiane, Rochat, Hervé, Lippens, Guy, El Ayeb, Mohamed, De Waard, Michel, Mabrouk, Kamel, Sabatier, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223841/
https://ncbi.nlm.nih.gov/pubmed/14498829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030977
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