Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects.

Systematic deletions and point mutations in the C-terminal extension of mammalian PFK (phosphofructokinase) led us to identify Leu-767 and Glu-768 of the M-type isoform (PFK-M) as the motifs responsible for the role of this region in inhibition by MgATP. These amino acids are the only residues of th...

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Detaylı Bibliyografya
Asıl Yazarlar: Martínez-Costa, Oscar H, Hermida, Carmen, Sánchez-Martínez, Cristina, Santamaría, Belén, Aragón, Juan J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2004
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223835/
https://ncbi.nlm.nih.gov/pubmed/12974670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031032
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