The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.

Pi1 is a 35-residue scorpion toxin cross-linked by four disulphide bridges that acts potently on both small-conductance Ca2+-activated (SK) and voltage-gated (Kv) K+ channel subtypes. Two approaches were used to investigate the relative contribution of the Pi1 functional dyad (Tyr-33 and Lys-24) to...

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Detalhes bibliográficos
Principais autores: Mouhat, Stéphanie, Mosbah, Amor, Visan, Violeta, Wulff, Heike, Delepierre, Muriel, Darbon, Hervé, Grissmer, Stephan, De Waard, Michel, Sabatier, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223833/
https://ncbi.nlm.nih.gov/pubmed/12962541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030115
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