Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary cells.

We have developed an expression system for the production of large quantities of recombinant MUC1 mucin in CHO-K1 (Chinese-hamster ovary K1) cells. The extracellular part of human MUC1, including 16 MUC1 tandem repeats, was produced as a fusion protein with murine IgG Fc, with an intervening enterok...

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Detalles Bibliográficos
Main Authors: Bäckström, Malin, Link, Thomas, Olson, Fredrik J, Karlsson, Hasse, Graham, Rosalind, Picco, Gianfranco, Burchell, Joy, Taylor-Papadimitriou, Joyce, Noll, Thomas, Hansson, Gunnar C
Formato: Artigo
Idioma:Inglês
Publicado: 2003
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223800/
https://ncbi.nlm.nih.gov/pubmed/12950230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031130
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