Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.

To investigate the hypothesis that decreased hapten flexibility may lead to increased catalytic antibody activity, we used two closely related immunogens differing only in the flexibility of the atomic framework around the structural motif of the haptens, analogous to the reaction centre of the corr...

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Detalhes bibliográficos
Main Authors: Gul, Sheraz, Sonkaria, Sanjiv, Pinitglang, Surapong, Florez-Alvarez, José, Hussain, Syeed, Thomas, Emrys W, Ostler, Elizabeth L, Gallacher, Gerard, Resmini, Marina, Brocklehurst, Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223799/
https://ncbi.nlm.nih.gov/pubmed/12946271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030716
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